Treat, 130 (2011), pp. 307–317.
19-
J.H. Law, G. Habibi, K. Hu,
et al.
Phosphorylated insulin-like growth factor-
i/insulin receptor is present in all breast cancer subtypes and is related to poor
survival.
Cancer Res, 68 (2008), pp. 10238–10246.
20-
L.H. Saal, P. Johansson, K. Holm,
et al.
Poor prognosis in carcinoma is
associated with a gene expression signature of aberrant PTEN tumor suppressor
pathway activity.
Proc Natl Acad Sci U S A, 104 (2007), pp. 7564–7569.
21-
T.W. Miller, B.N. Rexer, J.T. Garrett, C.L. Arteaga. Mutations in the
phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic
implications in breast cancer.
Breast Cancer Res, 13 (2011), p. 224.
22-
J. Baselga, V. Semiglazov, P. van Dam,
et al.
Phase II randomized study of
neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in
patients with estrogen receptor-positive breast cancer.
J Clin Oncol, 27 (2009), pp.
2630–2637.
23-
N. Shoman, S. Klassen, A. McFadden, M.G. Bickis, E. Torlakovic, R. Chibbar.
Reduced PTEN expression predicts relapse in patients with breast carcinoma treated
by tamoxifen.
Mod Pathol, 18 (2005), pp. 250–259.
24-
M. Maurer, T. Su, L.H. Saal,
et al.
3-Phosphoinositide-dependent kinase 1
potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast
carcinoma.
Cancer Res, 69 (2009), pp. 6299–6306.
25-
M.J. Ellis, Y. Tao, O. Young,
et al.
Estrogen-independent proliferation is
present in estrogen-receptor HER2-positive primary breast cancer after neoadjuvant
letrozole.
J Clin Oncol, 24 (2006), pp. 3019–3025.
26-
M. De Laurentiis, G. Arpino, E. Massarelli,
et al.
A meta-analysis on the
interaction between HER-2 expression and response to endocrine treatment in
advanced breast cancer.
Clin Cancer Res, 11 (2005), pp. 4741–4748.
27-
S. Loi, B. Haibe-Kains, S. Majjaj,
et al.
PIK3CA mutations associated with
gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-
positive breast cancer.
Proc Natl Acad Sci U S A, 107 (2010), pp. 10208–10213.
28-
B.T. Hennessy, A.M. Gonzalez-Angulo, K. Stemke-Hale,
et al.
Characterization of a naturally occurring breast cancer subset enriched in epithelial-
to-mesenchymal transition and stem cell characteristics.
Cancer Res, 69 (2009), pp.
4116–4124.
17