Cour RPC Sein 2016 - page 114

L'identification des cancers moléculaires apocrines par IHC est une méthode imparfaite et
plusieurs études utilisant des signatures d'expression sont en cours de développement
11]
. Une signature prédictive de la réponse à l'enzulatamide a été présentée sous forme
d'abstract
. Par ailleurs nous présenterons les différentes études cliniques en cours ou
en développement.
Références
1.
Farmer P, Bonnefoi H, Becette V et al. Identification of molecular apocrine breast
tumours by microarray analysis. Oncogene 2005; 24: 4660-4671.
2.
Doane AS DM, Lal P, Donaton M, Zhang L, Hudis C, Gerald WL. An estrogen
receptor-negative breast cancer subset characterized by a hormonally regulated
transcriptional program and response to androgen. Oncogene 2006; 25: 1-15.
3.
Guedj M, Marisa L, de Reynies A et al. A refined molecular taxonomy of breast
cancer. Oncogene 2012; 31: 1196-1206.
4.
Lehmann BD, Bauer JA, Chen X et al. Identification of human triple-negative breast
cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest
2011; 121: 2750-2767.
5.
Collins LC, Cole KS, Marotti JD et al. Androgen receptor expression in breast cancer
in relation to molecular phenotype: results from the Nurses' Health Study. Mod Pathol 2011;
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6.
Binder-Foucard F, Rasamimanana Cerf N, Belot A, Bossard N. Estimation nationale
de l’incidence et de la mortalité par cancer en France entre 1980 et 2012. Étude à partir des
registres des cancers du réseau Francim. Institut de veille sanitaire
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2013; 52-55.
7.
Lehmann-Che J, Hamy AS, Porcher R et al. Molecular apocrine breast cancers are
aggressive estrogen receptor negative tumors overexpressing either HER2 or GCDFP15.
Breast Cancer Res 2013; 15: R37.
8.
Gucalp A, Tolaney S, Isakoff SJ et al. Phase II trial of bicalutamide in patients with
androgen receptor-positive, estrogen receptor-negative metastatic Breast Cancer. Clin
Cancer Res 2013; 19: 5505-5512.
9.
Traina TA, Miller K, Yardley DA et al. Results of a phase 2 study of enzalutamide, an
androgen receptor (AR) inhibitor, in advanced AR+ triple-negative breast cancer. ASCO
2015; abstract 1003.
10.
Bonnefoi H, Grellety T, Tredan O et al. (last author A. Goncalves). A phase II trial of
abiraterone acetate plus prednisone in patients with a molecular apocrine HER2-negative
locally advanced or metastatic breast cancer (UCBG 2012-1). 2016 (under review)
11.
Parker JS, Peterson AC, Tudor IC et al. A novel biomarker to predict sensitivity to
enzalutamide in triple-negative breast cancer. ASCO 2015; Abstract 1083.
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