 
          Table 1 : Groupes pronostiques Métastases cérébrales du Cancer du sein
        
        
          D’apres Sperduto, IJROBP, 2012
        
        
          Facteur
        
        
          0
        
        
          0.5
        
        
          1.0
        
        
          1.5
        
        
          2.0
        
        
          Index
        
        
          de
        
        
          Karnofsky
        
        
          ≤ 50
        
        
          60
        
        
          70-80
        
        
          90-100
        
        
          Type
        
        
          moléculaire
        
        
          Basal
        
        
          -
        
        
          Luminal A
        
        
          HER2
        
        
          Luminal B
        
        
          Age
        
        
          ≥ 60 ans
        
        
          < 60 ans
        
        
          Etablissement
        
        
          de
        
        
          4
        
        
          groupes
        
        
          pronostiques
        
        
          selon le score
        
        
          1
        
        
          1 à 2
        
        
          2.5 à 3
        
        
          > 3
        
        
          Survie médiane en mois
        
        
          3.4
        
        
          7.7
        
        
          15.2
        
        
          25
        
        
          1.
        
        
          Pestalozzi BC, Zahrieh D, Price KN, Holmberg SB, Lindtner J, Collins J, et al.
        
        
          Identifying breast cancer patients at risk for Central Nervous System (CNS) metastases
        
        
          in trials of the International Breast Cancer Study Group (IBCSG). Ann Oncol Off J Eur Soc
        
        
          Med Oncol ESMO. juin 2006;17(6):935
        
        
          ‑
        
        
          44.
        
        
          2.
        
        
          Lin NU, Winer EP. Brain metastases: the HER2 paradigm. Clin Cancer Res Off J Am
        
        
          Assoc Cancer Res. 15 mars 2007;13(6):1648
        
        
          ‑
        
        
          55.
        
        
          3.
        
        
          Sperduto PW, Kased N, Roberge D, Xu Z, Shanley R, Luo X, et al. Effect of tumor
        
        
          subtype on survival and the graded prognostic assessment for patients with breast
        
        
          cancer and brain metastases. Int J Radiat Oncol Biol Phys. 1 avr 2012;82(5):2111
        
        
          ‑
        
        
          7.
        
        
          4.
        
        
          Patil CG, Pricola K, Garg SK, Bryant A, Black KL. Whole brain radiation therapy
        
        
          (WBRT) alone versus WBRT and radiosurgery for the treatment of brain metastases.
        
        
          Cochrane Database Syst Rev. 2010;(6):CD006121.
        
        
          5.
        
        
          Chang EL, Wefel JS, Hess KR, Allen PK, Lang FF, Kornguth DG, et al.
        
        
          Neurocognition in patients with brain metastases treated with radiosurgery or
        
        
          radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol.
        
        
          nov 2009;10(11):1037
        
        
          ‑
        
        
          44.
        
        
          6.
        
        
          Soon YY, Tham IWK, Lim KH, Koh WY, Lu JJ. Surgery or radiosurgery plus whole
        
        
          brain radiotherapy versus surgery or radiosurgery alone for brain metastases. Cochrane
        
        
          Database Syst Rev. 2014;3:CD009454.
        
        
          7.
        
        
          Kocher M, Soffietti R, Abacioglu U, Villà S, Fauchon F, Baumert BG, et al. Adjuvant
        
        
          whole-brain radiotherapy versus observation after radiosurgery or surgical resection of
        
        
          one to three cerebral metastases: results of the EORTC 22952-26001 study. J Clin Oncol
        
        
          Off J Am Soc Clin Oncol. 10 janv 2011;29(2):134
        
        
          ‑
        
        
          41.
        
        
          8.
        
        
          Yang TJ, Oh JH, Folkert MR, Gupta G, Shi W, Zhang Z, et al. Outcomes and
        
        
          prognostic factors in women with 1 to 3 breast cancer brain metastases treated with
        
        
          definitive stereotactic radiosurgery. Int J Radiat Oncol Biol Phys. 1 nov